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Hypertension after heart and heart/lung transplantation in childhood – Study on the evolution of short‐term blood pressure regulation
Author(s) -
Kohler Sarah M.,
Reisner Judith,
KozlikFeldmann Rainer,
Januszewska Katarzyna,
Netz Heinrich,
Pozza Robert Dalla
Publication year - 2011
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01580.x
Subject(s) - medicine , cardiology , heart transplantation , blood pressure , heart lung transplantation , heart failure , lung transplantation , lung , pulmonary hypertension , transplantation , heart rate
Kohler SM, Reisner J, Kozlik‐Feldmann R, Januszewska K, Netz H, Pozza RD. Hypertension after heart and heart/lung transplantation in childhood – Study on the evolution of short‐term blood pressure regulation.
Pediatr Transplantation 2011: 15: 804–808. © 2011 John Wiley & Sons A/S. Abstract: Arterial hypertension complicates the follow‐up of heart‐ and heart/lung‐transplanted children. We investigated the evolution of BRS as short‐time BP regulation mechanism and BP after heart and heart/lung transplantation. Twenty patients (15 males; mean age 15.1 ± 4.3 yr) were studied twice at intervals of 2.96 ± 0.87 yr. BRS was calculated using non‐invasive beat‐to‐beat BP measurement system. HRV was calculated (LF, sympathetic influence; HF, parasympathetic influence). BRS increased in 10 patients (3.67 ± 1.43 ms/mmHg vs. 7.59 ± 3.40 mmHg, p = 0.005) (group 1). Six of 10 patients received antihypertensive medication. BRS decreased or remained unchanged in 10 patients (8.93 ± 7.9 ms/mmHg vs. 5.32 ± 6.6 ms/mmHg, p = 0.008) (group 2) with 9/10 patients necessitating antihypertensive medication. Group 1 showed LF/HF increase (LF/HF 1.03 ± 0.9 vs. 4.36 ± 2.32, p = 0.03); group 2 showed LF/HF decrease (LF/HF 3.7 ± 2.1 vs. 1.84 ± 1.1, p = 0.023). Evolution of BRS after heart and heart/lung transplantation in childhood seems to influence the necessity of antihypertensive medication. With time, increasing short‐time BP regulation involving sympathetic reinnervation may improve BP.