Premium
Liver transplantation for severe hepatitis in patients with common variable immunodeficiency
Author(s) -
Murakawa Yasuhiro,
MiyagawaHayashino Aya,
Ogura Yasuhiro,
Egawa Hiroto,
Okamoto Shinya,
Soejima Yuji,
Kurosawa Manabu,
Sumiyoshi Shinji,
Uemoto Shinji,
Haga Hironori
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01545.x
Subject(s) - medicine , common variable immunodeficiency , liver transplantation , enteropathy , immunology , pathogenesis , hypogammaglobulinemia , pathology , hepatitis , cd8 , transplantation , immune system , disease , antibody
Murakawa Y, Miyagawa‐Hayashino A, Ogura Y, Egawa H, Okamoto S, Soejima Y, Kurosawa M, Sumiyoshi S, Uemoto S, Haga H. Liver transplantation for severe hepatitis in patients with common variable immunodeficiency.
Pediatr Transplantation 2011. © 2011 John Wiley & Sons A/S. Abstract: CVID is a heterogeneous group of primary immunodeficiency diseases characterized by hypogammaglobulinemia, recurrent bacterial infections, and frequent autoimmune manifestations. The post‐transplant course of liver transplant recipients with CVID is rarely described. We report two patients with CVID complicated by severe enteropathy who underwent living donor liver transplantation for liver failure because of severe hepatitis. The post‐transplant course was complicated by recurrent acute rejection, leading to ductopenic rejection in one and recurrent hepatitis in the other. We reviewed the tissue samples histologically and immunohistochemically. Native livers showed submassive hepatocyte necrosis in one and cirrhotic liver with active hepatitis in the other, both with infiltration of CD8+ T cells accompanied by endothelialitis and bile duct damage; the intestine contained increased numbers of intraepithelial CD8+ T cells with apoptosis of epithelial cells. The liver allograft exhibited acute rejection, with prominent CD8+ T cells infiltrating the bile duct or endothelium. In the allograft following the diagnosis of post‐transplant recurrent hepatitis, CD8+ T cells comprised the majority of infiltrating cells in portal areas spilling over into hepatic parenchyma. Our cases suggest that T cells contribute to the pathogenesis of CVID in native organs as well as allografts and may constitute evidence of T‐cell deregulation in the pathogenesis of CVID.