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Factors predicting persistent thrombocytopenia after living donor liver transplantation in pediatric patients
Author(s) -
Honda Masaki,
Yamamoto Hidekazu,
Hayashida Shintaro,
Suda Hiroko,
Ohya Yuki,
Lee KwangJong,
Takeichi Takayuki,
Asonuma Katsuhiro,
Inomata Yukihiro
Publication year - 2011
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01533.x
Subject(s) - medicine , incidence (geometry) , liver transplantation , platelet , living donor liver transplantation , surgery , multivariate analysis , univariate analysis , transplantation , gastroenterology , physics , optics
Honda M, Yamamoto H, Hayashida S, Suda H, Ohya Y, Lee K‐J, Takeichi T, Asonuma K, Inomata Y. Factors predicting persistent thrombocytopenia after living donor liver transplantation in pediatric patients.
Pediatr Transplantation 2011: 15: 601–605. © 2011 John Wiley & Sons A/S. Abstract: Thrombocytopenia is common after LT for pediatric end‐stage liver diseases. Seventy‐six pediatric patients (≤15 yr old) who underwent LDLT were evaluated for the incidence and predictive factors of post‐transplant thrombocytopenia (PLT <100 000/mm 3 ). The prevalence of thrombocytopenia at two wk and at 12 months post‐transplant was 22/76 (28.9%) and 11/62 (17.7%), respectively. Thrombocytopenia at two wk after LDLT was significantly associated with age at transplant, preoperative PLT, GRWR, acute rejection, and CMV infection in univariate analysis. Moreover, preoperative PLT, GRWR, and acute rejection had a strong correlation in multivariate analysis. Thrombocytopenia at 12 months after LDLT was associated only with preoperative PLT. We also demonstrated that vascular complications caused thrombocytopenia and that successful treatment recovered the PLT. These results showed that, in addition to considering the preoperative PLT, post‐operative monitoring of platelets is very helpful for the early detection of adverse events related to the graft liver in pediatric liver transplant patients.