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Vitamin D status in children and adolescents with kidney transplants
Author(s) -
Brodersen Louise Aarup,
Nielsen Pia Rude,
Thiesson Helle Charlotte,
Marckmann Peter
Publication year - 2011
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01493.x
Subject(s) - medicine , vitamin d and neurology , calcifediol , hypovitaminosis , vitamin d deficiency , kidney transplantation , endocrinology , transplantation , population , calcium metabolism , vitamin , cohort , kidney transplant , kidney , calcium , environmental health
Brodersen LA, Nielsen PR, Thiesson HC, Marckmann P. Vitamin D status in children and adolescents with kidney transplants.
Pediatr Transplantation 2011: 15: 384–389. © 2011 John Wiley & Sons A/S. Abstract: Hypovitaminosis D is highly prevalent in adult kidney‐transplanted patients. The knowledge of vitamin D status in kidney‐transplanted children and adolescents is sparse. The present study investigated the vitamin D status of a cohort of kidney‐transplanted children and adolescents, and the association between vitamin D status and plasma concentrations of PTH, ionized calcium, and phosphate. The study included 35 patients with a functioning graft. Their mean age was 12.0 yr, and the mean graft age was 2.8 yr. Forty percent of the patients were vitamin D insufficient (P‐25‐hydroxyvitamin D 40–75 n m ), and 14% were deficient (P‐25‐hydroxyvitamin D < 40 n m ). S‐25‐hydroxyvitamin D was inversely associated with PTH (p = 0.02) and positively associated with S‐1,25‐dihydroxyvitamin D (p = 0.02). There was no significant association between S‐1,25‐dihydroxyvitamin D and PTH. In conclusion, we found hypovitaminosis D in 54% of the study population despite the fact that samples were collected in spring and summer months. Hypovitaminosis D was associated with adverse effects on PTH and 1,25‐dihydroxyvitamin D. Our data suggest that it is warranted to monitor vitamin D status of kidney‐transplanted children and adolescents and indicate that correction of hypovitaminosis D might have favorable effects on calcium–phosphate metabolism.