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Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation
Author(s) -
Ansari Marc,
Rougemont AnneLaure,
Le Deist Françoise,
Ozsahin Hulya,
Duval Michel,
Champagne Martin A.,
Fournet JeanChristophe
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2011.01487.x
Subject(s) - medicine , pulmonary alveolar proteinosis , transplantation , cord blood , hematopoietic stem cell transplantation , pathology , etiology , haematopoiesis , eosinophilic , lung , immunology , stem cell , biology , genetics
Ansari M, Rougemont A‐L, Le Deist F, Ozsahin H, Duval M, Champagne MA, Fournet J‐C. Secondary pulmonary alveolar proteinosis after unrelated cord blood hematopoietic cell transplantation. Abstract: PAP is a rare alveolointerstitial lung disorder characterized histologically by the intra‐alveolar accumulation of eosinophilic and PAS‐positive material. We observed two cases of PAP after unrelated CB hematopoietic progenitor cell transplantation in children with ALL. No antagonist activity toward GM‐CSF was identified in the patient tested. The putative multifactorial PAP etiology is discussed. This potentially curable condition should be considered in a CB allograft recipient with alveolointerstial lung disorder.