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The utility of comprehensive assessment of donor specific anti‐HLA antibodies in the clinical management of pediatric kidney transplant recipients
Author(s) -
Gloor James M.
Publication year - 2011
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2010.01455.x
Subject(s) - medicine , human leukocyte antigen , antibody , transplantation , kidney transplantation , donor specific antibodies , kidney transplant , immunology , intensive care medicine , antigen
Gloor JM. The utility of comprehensive assessment of donor specific anti‐HLA antibodies in the clinical management of pediatric kidney transplant recipients.
Pediatr Transplantation 2011: 15: 557–563. © 2010 John Wiley & Sons A/S. Abstract: Advances in anti‐HLA antibody characterization have had a major impact on kidney transplantation. Comprehensive characterization of DSA has improved protocols for allosensitized transplant candidates, increasing access to acceptable donors. Sensitive and specific solid phase antibody detection assays have given important insight into the clinical characteristics of antibody‐mediated allograft injury, resulting in the development of a classification system for acute AMR. In addition, important insights into the nature of chronic antibody‐mediated allograft rejection have been achieved as a result of improvements in DSA characterization. Finally, assays initially developed as tools to detect DSA in the clinical setting have been employed in innovative research protocols, allowing the investigation of new therapeutic approaches.