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Treatment of adenovirus hepatitis with cidofovir in a pediatric liver transplant recipient
Author(s) -
Cimsit Bayindir,
Tichy Eric M.,
Patel Sonya B.,
Rosencrantz Richard,
Emre Sukru
Publication year - 2012
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2010.01443.x
Subject(s) - cidofovir , medicine , immunosuppression , liver biopsy , transplantation , liver transplantation , gastroenterology , hepatitis , liver disease , virology , immunology , biopsy , virus
Cimsit B, Tichy EM, Patel SB, Rosencrantz R, Emre S. Treatment of adenovirus hepatitis with cidofovir in a pediatric liver transplant recipient. Abstract: AdV hepatitis is a rarely reported complication after pediatric liver transplantation that is associated with high rates of morbidity, mortality and graft failure. Successful treatment of AdV relies on early diagnosis of disease by quantitative PCR measurement of adenoviral DNA in blood and histological evidence in tissue biopsy. Pharmacologic treatment largely consists of antiviral therapy with CDV, an acyclic nucleoside phosphonate analog and reduction in immunosuppression. This report describes a case of AdV hepatitis in a pediatric liver transplant recipient successfully treated with a modified, renal sparing dosing of CDV.