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Donor specific antibodies after transplantation
Author(s) -
Platt Jeffrey L.,
Cascalho Marilia
Publication year - 2011
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2010.01436.x
Subject(s) - alloimmunity , medicine , antibody , transplantation , donor specific antibodies , immunology , immunity , intensive care medicine , immune system , kidney transplantation
Platt JL, Cascalho M. Donor specific antibodies after transplantation.
Pediatr Transplantation 2011: 15: 686–690. © 2011 John Wiley & Sons A/S. Abstract: The detection of donor‐specific antibodies after organ transplantation might provide an incisive way to monitor allo‐specific immunity and predict graft outcome. Still, the availability of new assays for these antibodies prompts us to pose some questions about results that might be observed. These questions include whether the antibodies detected in the blood are a sensitive measure of alloimmunity, whether the detected antibodies are truly specific for the donor and whether they are noxious for the graft. Here, we explain why answers to these questions might interest the basic scientist and clinician.