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Platelet transfusion refractoriness attributable to HLA antibodies produced by donor‐derived cells after allogeneic bone marrow transplantation from one HLA‐antigen‐mismatched mother
Author(s) -
Hatakeyama Naoki,
Hori Tsukasa,
Yamamoto Masaki,
Inazawa Natsuko,
Iesato Kotoe,
Miyazaki Toru,
Ikeda Hisami,
Tsutsumi Hiroyuki,
Suzuki Nobuhiro
Publication year - 2011
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2010.01365.x
Subject(s) - medicine , human leukocyte antigen , immunology , antibody , antigen , transplantation , bone marrow , histocompatibility , isoantibodies , platelet , leukemia
Hatakeyama N, Hori T, Yamamoto M, Inazawa N, Iesato K, Miyazaki T, Ikeda H, Tsutsumi H, Suzuki N. Platelet transfusion refractoriness attributable to HLA antibodies produced by donor‐derived cells after allogeneic bone marrow transplantation from one HLA‐antigen‐mismatched mother.
Pediatr Transplantation 2011: 15: E177–E182. © 2010 John Wiley & Sons A/S. Abstract: PTR is a serious problem in patients being treated for hematologic disorders. Two patients with acute leukemia developed PTR after allogeneic BMT from one HLA‐antigen‐mismatched mother attributable to HLA antibodies, which could not be detected in their serum before BMT. HLA antibodies, whose specificity resembled that of each patient, were detected in each donor’s serum. Each donor had probably been immunized during pregnancy by their partner’s HLA antigens expressed by the fetus, consequently, transplanted donor‐derived cells provoked HLA antibodies in each recipient early after BMT, and those HLA antibodies induced PTR. If the mothers are selected as donors for their children, they should be tested for the presence of HLA antibodies.