Premium
Thrombotic events after pediatric liver transplantation
Author(s) -
Ooi Chee Yee,
Brandão Leonardo R.,
Zolpys Lauren,
De Angelis Maria,
Drew Wendy,
Jones Nicola,
Ling Simon C.,
Fecteau Annie,
Ng Vicky Lee
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2009.01252.x
Subject(s) - medicine , incidence (geometry) , liver transplantation , hematocrit , prospective cohort study , surgery , transplantation , pediatrics , physics , optics
Ooi CY, Brandão LR, Zolpys L, De Angelis M, Drew W, Jones N, Ling SC, Fecteau A, Ng VL. Thrombotic events after pediatric liver transplantation.
Pediatr Transplantation 2010: 14:476–482. © 2009 John Wiley & Sons A/S. Abstract: TE may contribute to morbidity and mortality after LT. The objectives were to determine the incidence of early TE post‐pediatric LT and compare differences between children with and without TE. A retrospective review of 88 transplanted children (January 2002–October 2007) was performed to determine the incidence of Doppler‐confirmed DVT and ATE in the first month post‐LT. Fourteen (16%) patients developed TE: DVT in seven (8%) and ATE in seven (8%) patients. Six of 88 (6.8%) developed symptomatic CVL‐related DVT. Median (range) time post‐LT to DVT and ATE were 7 (4–18) and 8 (1–31) days, respectively. There was no significant difference in age/body weight at LT between patients with or without DVT and ATE. There was no significant difference between patients with or without HAT in age and weight at LT, cold ischemic time, duration of surgery, hematocrit levels, whole‐organ graft type, intraoperative FFP, high‐risk CMV status, or early acute cellular rejection. In conclusion, the incidence of early TE post‐pediatric LT was 16%, including DVT in 8%. Prospective studies are necessary to evaluate the role of prophylactic anticoagulation and potential modifiable risk factors post‐pediatric LT.