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Successful second transplantation with non‐myeloablative conditioning using haploidentical donors for young patients after graft failure following double umbilical cord cell transplantation
Author(s) -
Liu Huilan,
Wang Xingbing,
Geng Liangquan,
Tang Baolin,
Tong Juan,
Yao Wen,
Wang Zuyi,
Sun Zimin
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2009.01231.x
Subject(s) - medicine , umbilical cord , transplantation , surgery , immunology
Liu H, Wang X, Geng L, Tang B, Tong J, Yao W, Wang Z, Sun Z. Successful second transplantation with non‐myeloablative conditioning using haploidentical donors for young patients after graft failure following double umbilical cord cell transplantation.
Pediatr Transplantation 2010: 14:465–470. © 2009 John Wiley & Sons A/S. Abstract: GF is a common and life‐threatening complication of UCBT. Here, we report that successful second transplantation of five patients using G‐CSF‐mobilized maternal stem cells with non‐myeloablative conditioning after GF following double UCBT. The median interval between the two transplants were 38 days. The first transplantation was administered after myeloablative conditioning for hematologic malignancies (n = 3), and rabbit ATG in combination with cyclophosphamide for SAA (n = 2). The second conditioning consisted of Flu and ATG‐based non‐myeloablative regimen. All five patients acquired quick and sustained engraftment after the second transplant. Treatment‐related toxicity was minimal. Three patients developed acute GVHD (>grade II = 1). Three patients developed chronic GVHD (limited = 1, extensive = 2). Severe infectious episodes were significant but manageable. With a median follow‐up of 713 days (592–1127), all patients have currently had an event‐free survival. These results indicate that a second transplant with non‐myeloablative conditioning using mother as the donor for young patient after GF is feasible.