Premium
Survival among children with portal vein thrombosis and end‐stage liver disease
Author(s) -
AlHolou Shaza,
Mathur Amit K.,
Ranney David,
Kubus James,
Englesbe Michael J.
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2009.01175.x
Subject(s) - medicine , portal vein thrombosis , thrombosis , portal vein , liver disease , liver transplantation , stage (stratigraphy) , model for end stage liver disease , surgery , radiology , transplantation , paleontology , biology
Al‐Holou S, Mathur AK, Ranney D, Kubus J, Englesbe MJ. Survival among children with portal vein thrombosis and end‐stage liver disease.
Pediatr Transplantation 2010: 14: 132–137. © 2009 John Wiley & Sons A/S. Abstract: Occlusive PVT concurrent with chronic liver disease is a common clinical entity among pediatric patients referred for transplantation. The natural history of PVT is unknown. Our aim was to determine, using a retrospective cohort design, if children under 13 yr with chronic liver disease and concomitant PVT have an increased mortality risk prior to and after transplantation. A total of 203 patients were included in the study. Nearly 10% of the population had PVT (n = 19); 63.2% of PVT patients (5.9% of total cohort) underwent liver transplantation (n = 12). PVT patients tended to be younger than non‐PVT patients at evaluation (1.94 ± 3.51 vs. 3.79 ± 4.11, p = 0.059). Clinical and demographic factors were similar between the two groups. Regarding survival, four PVT patients died, of which two had undergone transplantation. Kaplan–Meier analyses indicated that PVT and non‐PVT patients had similar survival from the time of evaluation, on the waiting list, and after transplant. Although limited by sample size, our study suggests that a diagnosis of PVT does not increase the mortality risk for children waiting for a liver transplant. Further study is needed to discern variations in mortality risk that may occur in the pediatric chronic liver disease population with PVT.