Premium
Prevalence of polyomavirus viruria (JC virus/BK virus) in children following liver transplantation
Author(s) -
Brinkert Florian,
BriemRichter Andrea,
Ilchmann Corina,
Kemper Markus J.,
Ganschow Rainer
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2009.01139.x
Subject(s) - bk virus , jc virus , medicine , polyomavirus infections , transplantation , liver transplantation , virology , nephropathy , virus , gastroenterology , kidney transplantation , immunology , progressive multifocal leukoencephalopathy , diabetes mellitus , endocrinology
Brinkert F, Briem‐Richter A, Ilchmann C, Kemper MJ, Ganschow R. Prevalence of polyomavirus viruria (JC virus/BK virus) in children following liver transplantation.
Pediatr Transplantation 2010: 14: 105–108. © 2009 John Wiley & Sons A/S. Abstract: BKV infection is a potential cause of renal dysfunction in non‐renal organ transplant recipients. JCV is the causative agent of PML. Furthermore, polyomaviruses are tumor inducing viruses and molecular data suggest an association with malignancies among solid organ transplant patients. So far, there are no studies analyzing polyomavirus viruria following Ltx in children. We performed a prospective prevalence study at a mean of 2187 (range 20–5671) days after transplantation in 100 consecutive children admitted for the routine follow‐up examination post‐Ltx. The urine was screened for BKV and JCV DNA by using PCR in each case. A plasma analysis by PCR was also done if more than 100 000 DNA copies/mL urine were detected. BKV or JCV viruria was found in 19% (n = 19) of our patients. All patients were free of clinical signs of viral infection, PML, or nephropathy. GFR was normal in 97% of patients and we found no statistical difference of kidney function between patients with and without BKV/JCV viruria. The extent of immunosuppressive therapy had no influence on the polyomavirus viruria. Overall, we found a higher prevalence of polyomavirus viruria in our pediatric liver transplant recipients than reported in adult patients.