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Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report
Author(s) -
Woolfrey Ann,
Storek Jan,
Bowyer Suzanne,
Nelson Robert,
Robertson Michael,
Wallace Carol
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2009.01129.x
Subject(s) - medicine , total body irradiation , refractory (planetary science) , regimen , arthritis , conditioning regimen , juvenile , transplantation , refractory period , surgery , hematopoietic stem cell transplantation , chemotherapy , cyclophosphamide , physics , astrobiology , biology , genetics
Woolfrey A, Storek J, Bowyer S, Nelson R, Robertson M, Wallace C. Long‐term response of juvenile idiopathic arthritis after conditioning with 8 Gy total body irradiation followed by autologous peripheral blood stem cells: Case report.
Pediatr Transplantation 2010: 14:E65–E69. © 2009 John Wiley & Sons A/S. Abstract: Investigations of HCT for refractory JIA have employed high dose immunosuppressive drugs, such as CY and ATG with or without low dose TBI. Initial disease response has been observed in approximately two‐thirds of patients; however, relapse occurs in about half of the responders. The current report describes a regimen with substantially increased dose of TBI, previously shown to be associated with high rate of disease response in adult patients with refractory MS and severe SSc. We report outcome of the lead patient in this pilot study, who remains in complete remission now, five yr after HCT. This regimen should be considered for patients with JIA refractory to medical therapies, including previous low intensity regimen HCT.