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Native BK viral nephropathy in a pediatric heart transplant recipient
Author(s) -
Ali Farah N.,
Meehan Shane M.,
Pahl Elfriede,
Cohn Richard A.
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01127.x
Subject(s) - medicine , nephropathy , bk virus , proteinuria , heart transplantation , transplantation , cardiomyopathy , chronic allograft nephropathy , polyomavirus infections , kidney transplantation , gastroenterology , kidney , heart failure , endocrinology , diabetes mellitus
Ali FN, Meehan SM, Pahl E, Cohn RA. Native BK viral nephropathy in a pediatric heart transplant recipient.
Pediatr Transplantation 2010: 14:E38–E41. © 2009 Wiley Periodicals, Inc. Abstract: BK viral nephropathy is a well‐documented clinical entity in kidney transplant recipients and a significant cause of morbidity and allograft loss in affected patients. BK viral nephropathy in native kidneys of non‐kidney transplant recipients is relatively uncommon, but has been reported in adult patients. We report the occurrence of BK viral nephropathy in a pediatric heart transplant recipient. A 10‐yr‐old boy with past history of Ewing’s sarcoma underwent heart transplantation for dilated cardiomyopathy induced by previous chemotherapy with doxorubicin. Post‐transplant course was complicated by grade 3A rejection and CMV colitis. He was diagnosed with native BK viral nephropathy approximately 18 months post‐transplant due to mild, but persistent, elevation in serum creatinine associated with proteinuria. BK viral nephropathy affects non‐kidney transplant recipients, and a high index of suspicion is necessary for early diagnosis and management of this condition.