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Successful treatment of refractory Langerhans cell histiocytosis with pulmonary aspergillosis by reduced‐intensity conditioning cord blood transplantation
Author(s) -
Hatakeyama Naoki,
Hori Tsukasa,
Yamamoto Masaki,
Inazawa Natsuko,
Hirako Yoko,
Tsutsumi Hiroyuki,
Suzuki Nobuhiro
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01124.x
Subject(s) - medicine , langerhans cell histiocytosis , refractory (planetary science) , transplantation , aspergillosis , surgery , cyclophosphamide , regimen , cord blood , chemotherapy , immunology , disease , physics , astrobiology
Hatakeyama N, Hori T, Yamamoto M, Inazawa N, Hirako Y, Tsutsumi H, Suzuki N. Successful treatment of refractory Langerhans cell histiocytosis with pulmonary aspergillosis by reduced‐intensity conditioning cord blood transplantation.
Pediatr Transplantation 2010: 14: E4–E10. © 2009 Wiley Periodicals, Inc. Abstract: The prognosis of multisystem LCH in children with risk organ involvement is extremely poor when they fail to respond to conventional chemotherapy. In such patients, allogeneic SCT may produce complete and sustained remission; however, high‐dose myeloablative regimens are frequently associated with treatment‐related morbidity and mortality. More recently, allogeneic SCT following an RIC regimen has been performed as an alternative salvage approach. We describe a nine‐month‐old boy with refractory multisystem LCH with pulmonary aspergillosis who was successfully treated with reduced‐intensity cord blood transplantation.