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Caries‐, Candida ‐ and Candida antigen/antibody frequency in children after heart transplantation and children with congenital heart disease
Author(s) -
SiahiBenlarbi Rachida,
Nies Silke M.,
Sziegoleit Andreas,
Bauer Jürgen,
Schranz Dietmar,
Wetzel WilliEckhard
Publication year - 2010
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01115.x
Subject(s) - medicine , heart transplantation , antibody , heart disease , transplantation , immunology , disease
Siahi‐Benlarbi R, Nies SM, Sziegoleit A, Bauer J, Schranz D, Wetzel W‐E. Caries‐, Candida ‐ and Candida antigen/antibody frequency in children after heart transplantation and children with congenital heart disease.
Pediatr Transplantation 2010: 14:715–721. © 2008 Wiley Periodicals, Inc. Abstract: The aim of this study was to determine the incidence of oral/intestinal Candida colonization and Candida ‐antigen/antibody in immunosuppressed children after HTx (group III, n = 31), in children with CHD (group II, n = 24) and in children with healthy hearts (comparison group, group I, n = 23) aged 2–16 yr according to their dental status between 2004 and 2007. Candida species in saliva, dental plaque, carious lesions and stool were detected with Sabouraud‐/CHROMagar and Auxacolor system. Candida ‐specific‐antigen/antibody assays were used for serological diagnosis. Dental status was determined on the basis of the DMF/dmf(T/t)‐index. We found significant group differences in fecal Candida colonization (p = 0.027). In relation to dental status, oral Candida colonization increased within group III from 28.5% [DMF/dmf(T/t) = 0] to 66.7% [DMF/dmf(T/t) ≥ 1] up to 100.0% [D/d(T/t) ≥ 1], similar in groups I and II. Candida ‐mannan‐antigen was determined to be positive in 16.1% (HTx), 5.5% (CHD) and 13.0% (comparison group). We show correlation between oral Candida colonization and (carious) dental status. We assume that high oral Candida and their descending/resorption through the gastrointestinal tract may lead to serologic Candida accumulation or rather candidiasis. Therefore, healthy oral cavity (especially before/after HTx) is an important precondition to prevent Candida infections.