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Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet
Author(s) -
Hubacek Petr,
Keslova Petra,
Formankova Renata,
Pochop Pavel,
Cinek Ondrej,
Zajac Miroslav,
Lochmanova Jana,
Stary Jan,
Sedlacek Petr
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01070.x
Subject(s) - foscarnet , medicine , cidofovir , retinitis , cytomegalovirus , cytomegalovirus retinitis , encephalitis , virology , ganciclovir , hematopoietic stem cell transplantation , betaherpesvirinae , transplantation , immunology , herpesviridae , surgery , viral disease , human cytomegalovirus , virus
We report an 18‐yr‐old female patient with repeated CMV reactivations after HSCT treated by several pre‐emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV‐resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowlegde, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.