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Engraftment syndrome following allogeneic hematopoietic stem cell transplantation in children
Author(s) -
Nishio Nobuhiro,
Yagasaki Hiroshi,
Takahashi Yoshiyuki,
Hama Asahito,
Muramatsu Hideki,
Tanaka Makito,
Yoshida Nao,
Yoshimi Ayami,
Kudo Kazuko,
Ito Masafumi,
Kojima Seiji
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01068.x
Subject(s) - medicine , rash , complication , incidence (geometry) , univariate analysis , hematopoietic stem cell transplantation , transplantation , surgery , multivariate analysis , gastroenterology , physics , optics
Abstract: ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non‐cardiac pulmonary infiltrates. We evaluated the incidence, risk factors, and outcomes of ES following allogeneic SCT in children. Of 100 pediatric patients, 20 (20%) developed ES occurring at a median of 14 days (range 8–27 days) post‐transplant. Patients presented with fever (100%), skin rash (100%), diffuse pulmonary infiltration (25%), and body weight gain (85%). On multivariate analysis, significant risk factors for ES included younger age (<8 yr old) and human leukocyte antigen disparity between donors and recipients. Univariate analysis showed that patients with ES had a higher incidence of developing chronic graft‐versus‐host disease and ES was not associated with other complications. Event‐free survival did not significantly differ between patients with and without ES regardless of the presence of malignant or non‐malignant diseases.