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Success of a steroid‐minimization immunosuppression protocol for renal transplantation in the presence of donor‐specific antibodies
Author(s) -
Butani Lavjay,
Perez Richard V.,
Gallay Brian J.
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01025.x
Subject(s) - medicine , immunosuppression , regimen , kidney transplantation , steroid , transplantation , adverse effect , intensive care medicine , immunology , hormone
Steroid‐minimization regimens have gained tremendous popularity for renal Tx in the recent past since they are associated with lower metabolic complications and other adverse effects related to long‐term steroid exposure. Most such protocols have been restricted to low‐risk recipients due to the concern for acute rejection with steroid‐minimization. Herein, we report our experience in managing a child who received a positive flow cytometry cross‐match living donor kidney transplant with low titer DSA and was successfully managed using a steroid‐minimization drug regimen. The purpose of our report is to make pediatric transplant care providers aware of the feasibility of using a steroid‐minimization immunosuppression regimen even in children who have traditionally been perceived to be at higher risk for immunologic complications, allowing successful avoidance of steroid toxicity.