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Second transplant with two unrelated cord blood units for early graft failure after cord blood transplantation for thalassemia
Author(s) -
Jaing TangHer,
Hung IouJih,
Yang ChaoPing,
Tsai MingHorng,
Lee WenI,
Sun ChienFeng
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.01021.x
Subject(s) - medicine , thalassemia , methylprednisolone , transplantation , regimen , cord blood , surgery , hematopoietic stem cell transplantation , gastroenterology
Early GF is a frequent complication following hematopoietic stem cell transplantation for patients with thalassemia. We report the outcome of double‐unit CBT in three patients who developed early GF after CBT. The initial conditioning regimen consisted of i.v. Bu 14 mg/kg (day −9 to −6), i.v. Cy 200 mg/kg (day −5 to −2) and ATG at 120 mg/kg (day −4 to −1). They received GVHD prophylaxis with cyclosporine‐A from day −3 and a short course of methylprednisolone (1 mg/kg i.v., every 12 h on days 5–19 with a taper, thereafter 25% decrease every other day). The interval between two transplants was seven and 10 months. The retransplant recipients were preconditioned with i.v. Bu 14 mg/kg (day −7 to −4), i.v. Cy 120 mg/kg (day –3 to –2) and ATG at 150 mg/kg (day −5 to −1 and +1 to +5). GVHD prophylaxis regimen was the same as the first transplant. Neutrophil engraftment were observed in all patients between day +15 and +26. All are alive, between nine and 11 months after retransplant. Our group reported successful utilization of double umblical cord blood grafts in thalassemia patients with early GF.