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Clinical correlation between dyslipidemia and pediatric chronic allograft nephropathy
Author(s) -
Valavi Ehsan,
Otukesh Hasan,
Fereshtehnejad SeyedMohammad,
Sharifian Mostapha
Publication year - 2008
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.00981.x
Subject(s) - medicine , hyperlipidemia , dyslipidemia , transplantation , familial hypercholesterolemia , renal function , renal transplant , population , nephropathy , cholesterol , disease , gastroenterology , endocrinology , diabetes mellitus , environmental health
CAN refers to the progressive decline of renal function seen in some renal transplant recipients in association with alloantigen‐dependent and alloantigen‐independent factors. Hyperlipidemia is a known risk factor for cardiovascular disease and CAN in adult renal transplant recipients, whereas no data exist in the pediatric transplant population. In this cross‐sectional study, 62 renal transplant recipients (32 CAN vs. 30 non‐CAN) aged 5–18 yr and with the mean follow‐up time of 48 months (9–93) after transplantation were evaluated for lipid profile and renal function tests. Hyperlipidemia has high prevalence in our patients both pre‐ and post‐transplantation. Furthermore, hypercholesterolemia and high‐LDL cholesterol levels have significant association with CAN (p = 0.019 and p = 0.039, respectively). In pediatric recipients, hyperlipidemia and particularly hypercholesterolemia have significant association with CAN and adults may need specific therapy.