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Long‐lasting extracorporeal albumin dialysis in a child with end‐stage renal disease and severe cholestasis
Author(s) -
Javouhey Etienne,
Ranchin Bruno,
Lachaux Alain,
Boillot Olivier,
Martin Xavier,
Floret Daniel,
Cochat Pierre
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2008.00946.x
Subject(s) - medicine , liver transplantation , gastroenterology , vomiting , dialysis , transplantation , surgery , kidney disease
We report a case of long‐lasting MARS therapy as a bridge to liver–kidney transplantation. A 26‐month‐old girl with congenital tubulointerstitial nephritis and severe liver fibrosis was placed on MARS for an acute‐on‐chronic liver failure due to sepsis. She underwent two sessions with good tolerance and recovered her previous neurological status. On the basis of pruritus, sleep, and vomiting improvement, repeated MARS sessions were performed to bridge her to combined liver–kidney transplantation. During eight months, 40 sessions were performed with the MARSmini® kit and the MARS monitor ® (Gambro, Lyon, France). The treatment significantly decreased mean pruritus score from 2.2 ± 0.9 to 0.8 ± 0.6 night‐time awakening and vomiting episodes. Body weight, height, and HC were −3.2, −3.5 and −2.2 SDS before and −1.7, −4.2, −2.0 SDS after eight months on MARS therapy, respectively. The arm circumference/HC ratio increased from 0.28 to 0.31. Mean total bilirubin serum levels were 303 ± 72 μmol/L before and 214 ± 42 μmol/L after MARS cycles. Long‐lasting MARS dialysis is feasible in children, decreases adverse effects of severe chronic cholestasis, and may help to preserve nutritional status prior to combined liver–kidney transplantation.