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Transmission of type 1 diabetes by bone marrow transplantation: A case report
Author(s) -
Mellouli Fethi,
Ksouri Habib,
Torjmen Lamia,
Abdelkefi Abderrahman,
Ladeb Saloua,
Ben Othman Tarek,
Ben Hassen Assia,
Béjaoui Mohamed
Publication year - 2009
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00889.x
Subject(s) - medicine , complication , autoantibody , aplastic anemia , type 1 diabetes , human leukocyte antigen , transplantation , bone marrow transplantation , disease , immunology , diabetes mellitus , bone marrow , pediatrics , surgery , antibody , endocrinology , antigen
T1D after BMT constitutes a human model of autoimmune disease transmission. This case report refers to T1D onset after allogeneic HLA‐matched BMT in a six‐yr‐old recipient affected by aplastic anemia. The donor was his sister who had T1D. The recipient had a complication free course apart from grade 1 acute GVHD, which was resolved spontaneously. With the predictive value and significance of T1D‐associated autoantibodies, we tried to consolidate the T1D transfer possibility based on our patient characteristics and a literature review.