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Aspergillus “fungus ball” of the bladder after hematopoietic transplantation in a pediatric patient: Successful treatment with intravesical voriconazole and surgery
Author(s) -
GonzálezVicent Marta,
Lassaletta Alvaro,
LópezPino Miguel Angel,
RomeroTejada Juan Carlos,
De La FuenteTrabado Manuel,
Díaz Miguel Ángel
Publication year - 2008
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00871.x
Subject(s) - voriconazole , medicine , aspergillosis , surgery , complication , antifungal , hemorrhagic cystitis , genitourinary system , fungus , aspergillus , transplantation , hematopoietic stem cell transplantation , dermatology , microbiology and biotechnology , botany , immunology , biology
Aspergillosis is an important cause of mortality in allogeneic HSCT. A “fungus ball” formation of Aspergillus in the bladder has seldom been reported. We report a child that underwent HSCT and developed possible disseminated aspergillosis with an intravesical “fungus ball,” diagnosed by genitourinary MRI and PCR of the mass that was removed from the bladder. It is important to consider this complication in a patient with HC after HSCT. The treatment included a combination of systemic antifungal therapy along with intravesical voriconazole and surgical removal.