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Successful unmanipulated peripheral blood progenitor cell transplantation from an HLA haploidentical 2‐locus‐mismatched mother in a thalassemic patient with primary graft failure after transplantation of bone marrow and cord blood from unrelated donors
Author(s) -
Jaing TangHer,
Sun ChienFeng,
Lee WenI,
Wen YuChuan,
Yang ChaoPing,
Hung IouJih
Publication year - 2008
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00844.x
Subject(s) - medicine , microchimerism , human leukocyte antigen , transplantation , thalassemia , cord blood , transplantation chimera , umbilical cord , histocompatibility testing , progenitor cell , bone marrow , surgery , stem cell , immunology , haematopoiesis , pregnancy , fetus , hematopoietic cell , antigen , kidney transplantation , genetics , biology
We report on a boy with β‐thalassemia major who developed early graft failure after double‐unit unrelated cord blood transplantation, who subsequently received a myeloablative preconditioning regimen using non‐T‐cell‐depleted PBSCT from his HLA‐haploidentical 2‐loci‐mismatched mother. Neutrophil recovery with full donor chimerism was observed at post‐transplantation day +11. Furthermore, GVHD was easy to control. The patient was transfusion‐independent with complete donor chimerism eight months post‐transplant. The result indicated that fetomaternal microchimerism may be an important attribute of a successful transplant. We suggested that a third allo‐HSCT may be taken into consideration for patients with transfusion‐dependent thalassemia who experience graft failure, even after two previous transplants.