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Outcomes of transplantation in children with primary hepatic malignancy
Author(s) -
Beaunoyer Mona,
Vanatta Jason M.,
Ogihara Makoto,
Strichartz Debra,
Dahl Gary,
Berquist William E.,
Castillo Ricardo O.,
Cox Kenneth L.,
Esquivel Carlos O.
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00751.x
Subject(s) - medicine , malignancy , transplantation , liver transplantation , primary (astronomy) , intensive care medicine , pediatrics , surgery , physics , astronomy
HBL and HCC are the most common hepatic malignancies in children. The role of OLT in children with HCC is still a matter of debate. The aim of this study was to review our experience of OLT for HCC. Medical records of patients (< 18 yr) who underwent OLT for HCC were reviewed and compared to children who underwent OLT for HBL and for indications other than malignancy. There were 25 patients: HCC (10 cases) and HBL (15 cases). The actuarial patient survival for HCC at one and five yr was 100% and 83.3%, for the HBL group the survival was 86.7% at both one and five yr, and for indications (n = 377) other than malignancy the patient survival for pediatric OLT at our center was 87.7% and 84.7% at one and five yr, respectively. The actuarial recurrence free survival at five yr was 83.3% for HCC and 66.8% for HBL. In conclusion, OLT is a good therapeutic modality for children with HCC and HBL.