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Successful pediatric living donor liver transplantation from carrier to carrier of hereditary butyrylcholinesterase variant
Author(s) -
Kawano Youichi,
Mizuta Koichi,
Hisikawa Shuji,
Saito Takeshi,
Egami Satoshi,
Takatsuka Yuka,
Sanada Yukihiro,
Fujiwara Takehito,
Yasuda Yoshikazu,
Ohmori Masami,
Sakamoto Koichi,
Liu Weidong,
Nishiguchi Shuhei,
Hada Toshikazu,
Kawarasaki Hideo
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00750.x
Subject(s) - medicine , contraindication , butyrylcholinesterase , liver transplantation , biliary atresia , surgery , immunosuppression , transplantation , pediatrics , gastroenterology , pathology , aché , biochemistry , chemistry , alternative medicine , acetylcholinesterase , enzyme
Hypocholinesterasemia is often observed clinically, especially in various liver diseases. Not well known, however, is the fact that some patients have a hereditary BChE variant. Little has been reported on liver transplants associated with this hereditary BChE variant. Furthermore, no cases have been reported of a LDLT involving hereditary BChE variant that had been diagnosed preoperatively. A 23‐month‐old girl who had had a failed Kasai operation for biliary atresia underwent a liver transplant using as a graft her father’s lateral segment. Preoperatively, she had been diagnosed with hypocholinesterasemia. As the donor, her father had undergone a preoperative examination, during which he was found to also have hypocholinesterasemia. DNA sequencing revealed that both had the hereditary BChE variant. The unique mutation caused a frame‐shift mutation. Variant K was also detected. The patient was discharged 143 days after the operation and has had no problems with immunosuppression since. In conclusion, we report that the hereditary BChE variant is not a contraindication for either transplantation or living liver donation.