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Unrelated cord blood transplantation in children with sickle cell disease: Review of four‐center experience
Author(s) -
Adamkiewicz Tom V.,
Szabolcs Paul,
Haight Ann,
Baker K. Scott,
Staba Susan,
Kedar Amos,
Chiang K. Y.,
Krishnamurti Lakshmanan,
Boyer Michael W.,
Kurtzberg Joan,
Wagner John E.,
Wingard John R.,
Yeager Andrew M.
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00725.x
Subject(s) - medicine , transplantation , graft versus host disease , disease , immunology , gastroenterology
UCBT was performed in seven children with SCD and stroke (HLA match 4/6 n = 5; 5/6 n = 2). Four received myeloablative regimens (BU, CY, ATG plus FLU in one patient). One had primary graft failure, three had sustained engraftment, two with grade III–IV GVHD (one died, one developed chronic GVHD), one with stable mixed chimerism. Three patients treated with reduced‐intensity regimens (FLU, BU or CY, ATG, TLI) failed to engraft; one engrafted after second UCBT (HU, TT, RXA, ALZ, TBI). Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges.