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Alkylator‐free conditioning regimen for patients with acquired aplastic anemia, transplanted from genetically identical twins
Author(s) -
Trakhtman P.,
Balashov D.,
Shipicina I.,
Skvortsova Y.,
Shelikhova L.,
Filimonov A.,
Novichkova G.,
Skorobogatova E.,
Maschan M.,
Maschan A.
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2007.00677.x
Subject(s) - conditioning regimen , medicine , conditioning , identical twins , transplantation , stem cell , aplastic anemia , immunosuppression , haematopoiesis , hematopoietic stem cell transplantation , toxicity , immunology , oncology , surgery , physiology , bone marrow , biology , genetics , statistics , mathematics
Allogeneic stem cell transplantation remains the best option for young patients with SAA. With genetically identical twin as an ideal donor, the majority of SAA patients require appropriate immunosuppression before and after stem cell transplantation to obtain long‐term hematopoietic reconstitution. Alkylating agents, used during conditioning, are associated with short‐ and long‐term toxic effects that lead to poor compliance of treatment and could compromise the quality of future life. Three SAA patients, transplanted from genetically identical twins without using alkylating agents during conditioning, showed rapid and sustained hematological reconstitution without any evidence of conditioning‐related toxicity.