Premium
Atypical skin graft‐vs.‐host disease following bone marrow transplantation in an infant
Author(s) -
Kuskonmaz B.,
Güçer S.,
Boztepe G.,
Cetin M.,
Uckan D.
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2006.00647.x
Subject(s) - medicine , rash , bone marrow transplantation , graft versus host disease , presentation (obstetrics) , disease , dermatology , transplantation , pathology , surgery
Herein, we describe an unusual presentation of acute graft versus host disease (GVHD) mimicking contact dermatitis in an infant who underwent 5/6 HLA‐matched bone marrow transplantation (BMT) from his mother for malignant infantile osteopetrosis. The initial rash on day +32 simulated diaper rash, which progressed to a belt‐shaped rash and then developed hyperkeratotic nodules on the hands. The acute GVHD was atypical and the course was progressive and fatal, with liver and gut involvement. This presentation of atypical initial skin involvement of acute GVHD may be useful for practicing clinicians in the BMT field who need to be aware of the early unusual signs of acute GVHD so that they can initiate prompt treatment.