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Risk factors for lower health‐related QoL after allogeneic stem cell transplantation in children
Author(s) -
Löf Catharina M.,
Forinder Ulla,
Winiarski Jacek
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2006.00630.x
Subject(s) - medicine , psychosocial , sibling , transplantation , leukemia , disease , quality of life (healthcare) , el niño , pediatrics , clinical psychology , psychiatry , developmental psychology , psychology , nursing
To explore risk factors affecting HrQoL, we analyzed data from patients (n = 51) at least three yr beyond SCT and their parents (n = 41), who responded to the SCHQ, to a subjective symptom inventory and to a sense of coherence instrument, in parallel with a physician‐rated scoring of late effects. Children with leukemia rated a lower HrQoL than children with non‐malignant disease only in subscale RE, limitations in role socially because of the emotional difficulties (p < 0.05) but had more severe late effects (p < 0.05). Parents of children with leukemia rated their children's HrQoL overall lower in both the psychosocial area and physical area (p < 0.01) and the child's condition also had a greater impact on parents’ emotional situation (p < 0.05), compared with parents of children with non‐malignant diagnosis. The psychosocial HrQoL was more affected in recipients of an unrelated than of a sibling graft, according to both child (p < 0.01) and parent (p < 0.05). In the multiple regression analysis, however, late effects remained the only independent factor, contributing to low parental psychosocial (p < 0.05) and physical (p < 0.001) HrQoL ratings, while leukemia, unrelated donor and TBI did not. To conclude, parent‐reported HrQoL was lower in SCT patients with leukemia, mainly due to a higher impact of late effects in this group.