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Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant?
Author(s) -
Faraci M.,
Cappelli B.,
Morreale G.,
Lanino E.,
Moroni C.,
Bandettini R.,
Terranova M. P.,
Di Martino D.,
Coccia C.,
Castagnola E.
Publication year - 2007
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2006.00622.x
Subject(s) - nitazoxanide , medicine , cryptosporidium , immunology , cryptosporidium parvum , gastroenterology , virology , feces , microbiology and biotechnology , biology
We describe a case of Cryptosporidium infection occurring in a child after allogeneic SCT for acute non‐lymphoblastic leukemia. This patient presented an intestinal, biliar, and pancreatic Cryptosporidium disease associated with an intestinal aGvHD. The increase in CD3+/CD4+ cells secondary to the reduction of steroid therapy associated with the improvement of aGvHD and the use of antiparasitic treatments (especially nitazoxanide) improved the infection‐related symptoms and led to a complete clearance of the Cryptosporidium.