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Chimerism in a child with severe combined immunodeficiency: A case report
Author(s) -
Aureli Anna,
Piancatelli Daniela,
Monaco Palmina I.,
Ozzella Giuseppina,
Canossi Angelica,
Piazza Antonina,
Isacchi Giancarlo,
Caniglia Maurizio,
Adorno Domenico
Publication year - 2006
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2006.00568.x
Subject(s) - severe combined immunodeficiency , medicine , hematopoietic stem cell transplantation , immunodeficiency , immunologic deficiency syndromes , primary immunodeficiency , lymphocyte , transplantation , immunology , pediatrics , hematopoietic cell , stem cell , peripheral blood , immunodeficiency syndrome , haematopoiesis , immune system , genetics , biology , gene
Severe combined immunodeficiency (SCID) represents a group of rare, sometimes fatal, congenital disorders in which there is a combined absence of T‐lymphocyte and B‐lymphocyte function. Children with SCID die within two years of age, if untreated. The effective treatment for SCID is a hematopoietic stem cell transplantation (HSCT). It has been repeatedly described that in peripheral blood of infants with SCID maternal T cells can be found. Here we report a case of blood chimerism in a one‐year‐old boy with SCID.