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Anti‐HLA alloantibodies in pediatric solid organ transplantation
Author(s) -
Girnita Alin L.,
Webber Steven A.,
Zeevi Adriana
Publication year - 2006
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2005.00425.x
Subject(s) - medicine , solid organ , human leukocyte antigen , transplantation , histocompatibility testing , isoantibodies , organ transplantation , immunology , antigen
An increasing number of studies demonstrate the clinical impact of preformed and de novo anti‐human leucocyte antigen alloantibody (HLA‐Ab) in solid organ transplantation (Tx). The screening of HLA‐Ab in candidates and transplant recipients has evolved over time, with continuous improvement in the sensitivity and specificity of assays for HLA‐Ab detection. Furthermore, histologic markers of complement activation pathways are currently implemented in the diagnosis of antibody‐mediated rejection (AMR). Therapeutic strategies, including depletion of HLA‐Ab and B cells, have allowed Tx across antibody barriers, or have rescued patients with AMR. The purpose of the present review is to summarize the state‐of‐the‐art of HLA‐Ab detection, clinical significance and therapeutic strategies in pediatric solid organ Tx.