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Specific autologous cytotoxic T lymphocytes for chronic varicella in a liver transplanted child
Author(s) -
Melzi Maria Luisa,
Sonzogni Aurelio,
Comoli Patrizia,
Stroppa Paola,
Riva Silvia,
Altobelli Monica,
Casati Annalia,
Torre Giuliano,
Alberti Daniele,
Guizzetti Michela,
Furione Milena,
Spada Marco,
Colledan Michele,
Gridelli Bruno
Publication year - 2006
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2005.00419.x
Subject(s) - medicine , ctl* , immunology , liver transplantation , cytotoxic t cell , cytolysis , varicella zoster virus , virus , vaccination , virology , transplantation , immune system , cd8 , biochemistry , chemistry , in vitro
Infections by herpesviruses may have severe complications in liver transplant patients. Although prophylactic varicella zoster virus vaccination is strongly recommended and widely applied, severe infection may still occur. We report the case of systemic chronic varicella, which developed in a liver allograft recipient, unresponsive to antiviral drug treatment, successfully treated by varicella zooster‐specific CTL. Graft failure ensued, likely, because of massive cytolysis of infected hepatocytes. The patient, who was re‐transplanted in the absence of signs of varicella zooster reactivation, is now well and disease free 3 yr after second liver transplant.