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The pediatric nephrotic syndrome spectrum: Clinical homogeneity and molecular heterogeneity
Author(s) -
Schachter Asher D.
Publication year - 2004
Publication title -
pediatric transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 69
eISSN - 1399-3046
pISSN - 1397-3142
DOI - 10.1111/j.1399-3046.2004.00179.x
Subject(s) - nephrotic syndrome , medicine , idiopathic nephrotic syndrome , congenital nephrotic syndrome , genetic heterogeneity , pediatrics , kidney , proteinuria , genetics , biology , gene , phenotype
Idiopathic nephrotic syndrome is the most common glomerular disorder of childhood. Recurrence of nephrotic syndrome immediately following renal transplantation is rapid, results in a high rate of graft loss, and represents the most severe form of nephrotic syndrome. This review discusses the molecular heterogeneity of pediatric nephrotic syndrome across the spectrum of disease activity. A schema is offered for a molecular approach to pediatric nephrotic syndrome, including immune‐mediated and structural/genetic factors.