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Phadiatop Infant ® detects IgE‐mediated diseases among pre‐school children: a prospective study
Author(s) -
Nilsson Caroline,
Lilja Gunnar,
Nordlund Monica,
Berthold Malin,
Borres Magnus P.
Publication year - 2012
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2011.01203.x
Subject(s) - medicine , sensitization , immunoglobulin e , prospective cohort study , allergy , odds ratio , immunology , pediatrics , antibody
To cite this article: Nilsson C, Lilja L, Nordlund M, Berthold M, Borres MP. Phadiatop Infant ® detects IgE‐mediated diseases among pre‐school children: a prospective study. Pediatr Allergy Immunol 2011; Doi: 10.1111/j.1399‐3038.2011.01203.x Abstract Background: IgE‐sensitization to food and inhalant allergens may precede and accompany the appearance of clinical symptoms of allergic diseases. The aim was to study the diagnostic capacity of Phadiatop ® Infant (Phinf) for detecting IgE‐sensitization at 5 yr of age and further to evaluate the predictive capacity of Phinf longitudinally with regard to sensitization and allergic symptoms in pre‐school children. Methods: Two hundred and one children with complete data on sIgE testing for 10 individual allergens, Phinf analyses, and clinical evaluations at 2 and 5 yr of age were evaluated. Results: The diagnostic performance of Phinf, applied at the age of 5 and compared to specific IgE testing, gave a sensitivity of 84% and a specificity of 98%. The positive and negative predictive values were 97% and 92%, respectively. A positive Phinf test at 2 yr increased the odds 35.6‐fold (95% CI 11.8–107) for IgE‐sensitization and 14.7‐fold (95% CI 4.4–49.7) for any allergic symptom at 5 yr of age. The association (OR) between Phinf and current symptoms was, at 2 and 5 yr of age, 3.6 (95% CI 1.6–7.9) and 18.4 (95% CI 7.4–45.8), respectively. Conclusions: Phinf seems to be a reliable tool for predicting future sensitization as well as allergic symptoms in young children.