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Vitamin D 3 deficiency enhances allergen‐induced lymphocyte responses in a mouse model of allergic airway disease
Author(s) -
Gorman Shelley,
Tan Daryl H. W.,
Lambert Misty J. M.,
Scott Naomi M.,
Judge Melinda A.,
Hart Prue H.
Publication year - 2012
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2011.01146.x
Subject(s) - medicine , ovalbumin , immunology , vitamin d and neurology , vitamin d deficiency , asthma , allergy , vitamin , allergen , immunoglobulin e , lymphocyte , immune system , endocrinology , antibody
To cite this article: Gorman S, Tan DHW, Lambert MJM, Scott NM, Judge MA, Hart PH. Vitamin D 3 deficiency enhances allergen‐induced lymphocyte responses in a mouse model of allergic airway disease. Pediatr Allergy Immunol 2012: 23 : 83–87 Abstract There is debate as to whether vitamin D deficiency contributes towards the extent of the asthma epidemic. In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. Using dietary restriction, vitamin D 3 ‐replete and vitamin D 3 ‐deficient colonies of BALB/c mice were established. Utilizing the allergic airway disease model of asthma with the experimental allergen ovalbumin (OVA), we examined asthma‐like responses 24 h after airway challenge with OVA in adult offspring born to vitamin D 3 ‐replete and vitamin D 3 ‐deficient mothers. The ability of airway‐draining lymph node cells to proliferate and secrete cytokines in response to OVA ex vivo was significantly enhanced by vitamin D 3 deficiency. However, other aspects of allergic disease, including the numbers and proportions of inflammatory cells and cytokines in the lungs and the quantity of OVA‐specific IgE in serum, were not modified. These results suggest that vitamin D 3 deficiency modulates the capacity of lymphocytes to respond to allergens.