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Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma
Author(s) -
Suh Dong I.,
Lee Ju K.,
Kim Chang K.,
Koh Young Y.
Publication year - 2011
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2010.01110.x
Subject(s) - atopy , medicine , methacholine , asthma , bronchial hyperresponsiveness , allergy , adenosine monophosphate , immunology , immunoglobulin e , spirometry , adenosine , respiratory disease , lung , antibody
To cite this article: Suh DI, Lee JK, Kim CK, Koh YY. Methacholine and adenosine 5′‐monophosphate (AMP) responsiveness, and the presence and degree of atopy in children with asthma. Pediatr Allergy Immunol 2011; 22 : e101–e106. Abstract The relationship between atopy and bronchial hyperresponsiveness (BHR), both key features of asthma, remains to be clarified. BHR is commonly evaluated by bronchial challenges using direct and indirect stimuli. The aim of this study was to investigate the degree of BHR to methacholine (direct stimulus) and adenosine 5′‐monophosphate (AMP) (indirect stimulus) according to the presence and degree of atopy in children with asthma. We performed a retrospective analysis of data from 120 children presenting with a diagnosis of asthma. These children were characterized by skin‐prick tests (SPTs), spirometry and bronchial challenges with methacholine and AMP. Atopy was defined by at least one positive reaction to SPTs, and its degree was measured using serum total IgE levels, number of positive SPTs and atopic scores (sum of graded wheal size). A provocative concentration causing a 20% decline in FEV 1 (PC 20 ) was determined for each challenge. Patients with atopy(n = 94) had a significantly lower AMP PC 20 than non‐atopic patients (n = 26), whereas methacholine PC 20 was not different between the two groups. Among the patients with atopy, there was no association between methacholine PC 20 and any atopy parameter. In contrast, a significant association was found between AMP PC 20 and the degree of atopy reflected in serum total IgE, number of positive SPTs and atopic scores ( anova trend test, p = 0.002, 0.001, 0.003, respectively). AMP responsiveness was associated with the presence and degree of atopy, whereas such a relationship was not observed for methacholine responsiveness. These findings suggest that atopic status may be better reflected by bronchial responsiveness assessed by AMP than by methacholine.