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Expression of Toll‐like receptors by neonatal leukocytes
Author(s) -
Dasari Pallave,
Zola Heddy,
Nicholson Ian C
Publication year - 2011
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2010.01091.x
Subject(s) - tlr2 , tlr9 , immunology , medicine , receptor , tlr4 , tlr3 , toll like receptor , flow cytometry , immune system , innate immune system , biology , gene expression , gene , biochemistry , dna methylation
To cite this article: Dasari P, Zola H, Nicholson IC. Expression of Toll‐like receptors by neonatal leukocytes. Pediatr Allergy Immunol 2011; 22 : 221–228. Abstract The immune system of neonates is poorly developed; this increases the susceptibility of neonates to infection. For neonates to counter infection effectively, they first need to recognize the presence of pathogens. Toll‐like receptors (TLR) are a family of pattern recognition receptors that alert the host to the presence of invading pathogens. To determine whether differences in TLR expression by leukocytes compensate for immunologic immaturity in neonates, TLR expression by monocytes and T lymphocytes from adults and neonates was compared. Expression of TLR1, TLR2, TLR3, TLR4, TLR8 and TLR9 by monocytes and T lymphocytes was detected with antibodies by flow cytometry. TLR1, TLR2, TLR3, TLR4, TLR8 and TLR9 expression by monocytes was detected in adults and neonates. TLR2, TLR3, TLR4, TLR8 and TLR9 expression by T lymphocytes was detected in adults and neonates. Monocytes and T lymphocytes from neonates are capable, like adults, of recognizing the presence of pathogens through TLR.