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Pediatric common variable immunodeficiency: Immunologic and phenotypic associations with switched memory B cells
Author(s) -
Yong Pierre L.,
Orange Jordan S.,
Sullivan Kathleen E.
Publication year - 2010
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2010.01004.x
Subject(s) - common variable immunodeficiency , medicine , immunology , bronchiectasis , immunodeficiency , group b , population , lung , immune system , antibody , environmental health
Yong PL, Orange JS, Sullivan KE. Pediatric common variable immunodeficiency: Immunologic and phenotypic associations with switched memory B cells.
Pediatr Allergy Immunol 2010: 21: 852–858.
© 2010 John Wiley & Sons A/S Recent studies suggest that patients with common variable immunodeficiency (CVID) and low numbers of switched memory B cells have lower IgG levels and higher rates of autoimmune disease, splenomegaly, and granulomatous disease; however, no prior literature has focused exclusively on pediatric cases. We examined the relationship between switched memory B cells and clinical and immunologic manifestations of CVID in a pediatric population. Forty‐five patients were evaluated. Patients were categorized as Group I (<5 switched memory B cells/ml, n = 24) or Group II (≥5 switched memory B cells/mL, n = 21). CD3 + T‐cell counts and CD19 + B‐cell levels were lower among Group I patients. Only those in Group I had meningitis, sepsis, bronchiectasis, granulomatous lung disease, autoimmune cytopenias, or hematologic malignancies. Segregation of pediatric patients into high risk (Group I) and average risk (Group II) may assist in targeting surveillance appropriately.