Premium
IL‐10 gene polymorphism, but not TGF‐β1 gene polymorphisms, is associated with food allergy in a Japanese population
Author(s) -
Campos Alberto Eduardo Jose,
Shimojo Naoki,
Suzuki Yoichi,
Mashimo Yoichi,
Arima Takayasu,
Matsuura Tomoko,
Inoue Yuzaburo,
Yamaide Akiko,
Tomiita Minako,
Fujii Katsunori,
Hata Akira,
Kohno Yoichi
Publication year - 2008
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2007.00709.x
Subject(s) - medicine , food allergy , allergy , odds ratio , polymorphism (computer science) , genotype , immunology , case control study , single nucleotide polymorphism , genetics , gene , biology
The regulatory IL‐10 and TGF‐β1 cytokine gene polymorphisms have been associated with allergic diseases in different populations, like Caucasian, Chinese and Indians. We investigated the association between the polymorphisms IL‐10 A−1082G, C−819T, C−627A and TGF‐β1 T+869C, G+915C, C−509T and food allergy in Japanese children. One hundred and eleven children with food allergy and 115 atopic control children without food allergy were recruited. DNA samples from these subjects were genotyped by using PCR. The odds ratio of IL‐10 −1082 AA genotype was 2.5 (95% CI, 1.0–6.4) for food allergy risk when compared with atopic control subjects (p = 0.03). There were no significative differences in the frequency of TGF‐β1 gene polymorphisms between both groups. Our results indicate that IL‐10 A−1082G gene polymorphism is associated with food allergy susceptibility in atopic Japanese children.