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Adverse reactions to simultaneous influenza and pneumococcal conjugate vaccinations in children: randomized double‐blind controlled trial
Author(s) -
Jansen Angelique G. S. C.,
Sanders Elisabeth A. M.,
Smulders Sara,
Hoes Arno W.,
Hak Eelko
Publication year - 2008
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2007.00681.x
Subject(s) - medicine , vaccination , adverse effect , placebo , pneumococcal conjugate vaccine , randomized controlled trial , pediatrics , respiratory tract infections , immunology , streptococcus pneumoniae , respiratory system , microbiology and biotechnology , antibiotics , alternative medicine , pathology , biology
In a randomized double‐blind controlled trial, the safety was assessed of simultaneous administration of influenza and pneumococcal conjugate vaccines in children with previous physician‐diagnosed respiratory tract infections. In total, 579 children aged 18–72 months were assigned to receive simultaneous intramuscular influenza and pneumococcal heptavalent conjugate vaccinations (IV + PV), influenza and placebo vaccinations (IV + plac) or control hepatitis B and placebo vaccinations (HepB + plac) in separate extremities. Local and systemic adverse events were recorded in parental diaries for 7 days after vaccination. No immediate adverse reactions were recorded. In most children local adverse reactions disappeared 2 days after vaccination. Local and systemic reactions were more prevalent (30% and 10% more) in the IV + PV group compared with the IV + plac and HepB + plac group. These results are important for designing future vaccination schedules.