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Apoptosis, airway inflammation and anti‐asthma therapy: From immunobiology to clinical application
Author(s) -
Spinozzi Fabrizio,
Benedictis Diletta de,
De Benedictis FM
Publication year - 2008
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2007.00668.x
Subject(s) - medicine , immunology , inflammation , immune system , apoptosis , asthma , allergy , homeostasis , airway , biology , biochemistry , surgery
T lymphocyte apoptosis is essential for maintaining immune system homeostasis. Experimental evidence suggests apoptosis control mechanisms may be impaired in inflammatory conditions, particularly airway Th2‐type allergic diseases. This review briefly examines the mucosal immune system homeostasis and common apoptotic pathways and discusses impaired apoptosis, allergy, airway inflammation, remodelling and fibrosis. Finally, the paper presents an update on pharmacological targeting of apoptosis to control airway inflammation in patients with allergic asthma.