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Educational clinical case series in pediatric allergy and immunology
Author(s) -
Khan Seema,
Kandula Leena,
Orenstein Susan R.
Publication year - 2007
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2007.00659.x
Subject(s) - eosinophilic esophagitis , medicine , eosinophilic gastroenteritis , mepolizumab , immunology , allergy , etiology , atopy , eosinophil , asthma , eotaxin , eosinophilic , pathogenesis , eosinophilia , dermatology , disease , pathology
Eosinophilic inflammation may occur in any part of the intestinal tract from the esophagus to the rectum. Despite 70 yr having passed since the first reference to a case of eosinophilic gastroenteritis, the epidemiology and natural history of eosinophilic gastrointestinal disorders are still poorly known. Insights into their etiology and pathogenesis have revealed an important role for allergens; interleukins 4, 5, and 13; the eotaxin family of chemokines; and eosinophil‐derived proteins. Diagnosis is confirmed by typical histologic features in a patient with a suggestive clinical phenotype. Treatment involves eliminating triggering allergens, making dietary restrictions the first choice of therapy in a compliant patient; corticosteroids [topical in eosinophilic esophagitis (EE)], despite the potential for serious side effects, are used with success in refractory and non‐compliant patients. In this study we discuss EE and gastroduodenitis against the backdrop of clinical case presentations.