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Fetal sensitization to cow's milk protein and wheat: cow's milk protein and wheat‐specific TNF‐ α production by umbilical cord blood cells and subsequent decline of TNF‐ α production by peripheral blood mononuclear cells following dietary intervention
Author(s) -
Ward Carla M.,
Geng Lee,
Jyonouchi Harumi
Publication year - 2007
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2007.00536.x
Subject(s) - medicine , sensitization , peripheral blood mononuclear cell , fetus , tumor necrosis factor alpha , umbilical cord , immunology , cord blood , immunoglobulin e , cytokine , pregnancy , physiology , endocrinology , antibody , biochemistry , biology , genetics , in vitro
We present a case of fetal sensitization to cow's milk protein (CMP) and wheat, resulting in non‐IgE mediated food allergy (NFA). Fetal sensitization was indicated by onset of NFA symptoms shortly after birth and CMP/wheat‐specific tumor necrosis factor‐ α (TNF‐ α ) production by cord blood mononuclear cells. Following dietary intervention, we observed a decline of TNF‐ α production by peripheral blood mononuclear cells with stimuli of these dietary proteins (DPs) but recurrence of reactivity was observed following viral gastroenteritis, while interleukin‐10 production with these DPs persisted during his first 5 yr of life. This finding may indicate active suppressive mechanisms for maintaining oral tolerance.