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Efficacy of donkey's milk in treating highly problematic cow's milk allergic children: An in vivo and in vitro study
Author(s) -
Monti Giovanna,
Bertino Enrico,
Muratore Maria Cristina,
Coscia Alessandra,
Cresi Francesco,
Silvestro Leandra,
Fabris Claudio,
Fortunato Donatella,
Giuffrida Maria Gabriella,
Conti Amedeo
Publication year - 2007
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2007.00521.x
Subject(s) - donkey , medicine , in vivo , in vitro , cow milk , immunology , food science , microbiology and biotechnology , biochemistry , chemistry , ecology , biology
Successful therapy in cow's milk protein allergy rests on completely eliminating cow's milk proteins from the child's diet: it is thus necessary to provide a replacement food. This prospective study investigated tolerance of donkey's milk in a population of 46 selected children with cow's milk protein allergy, for whom it was not possible to use any cow's milk substitute. Thirty‐eight children (82.6%) liked and tolerated donkey's milk at the challenge and for the entire duration of follow‐up. Catch‐up growth was observed in all subjects with growth deficit during cow's milk proteins challenge. The degree of cross‐reactivity of immunoglobulin E (IgE) with donkey's milk proteins was very weak and aspecific. Donkey's milk was found to be a valid alternative to both IgE‐mediated and non‐IgE‐mediated cow's milk proteins allergy, including in terms of palatability and weight‐height gain.