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Isolated IgG3 deficiency in children: to treat or not to treat? Case presentation and review of the literature
Author(s) -
Meyts Isabelle,
Bossuyt X,
Proesmans M,
De Boeck
Publication year - 2006
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2006.00454.x
Subject(s) - medicine , subclass , clinical significance , presentation (obstetrics) , pediatrics , immunology , iga deficiency , intensive care medicine , antibody , pathology , surgery
Immunoglobulin G3 (IgG3) subclass deficiency has received rather little attention thus far. In this report, the clinical and immunologic characteristics of six children with isolated IgG3 deficiency are discussed. The currently available literature on IgG3 deficiency is reviewed with specific emphasis on the peculiarities of the IgG3 subclass, the clinical relevance of IgG3 deficiency as well as the therapeutic options.