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Patterns of latex allergen recognition in children sensitized to natural rubber latex
Author(s) -
Pamies Rafael,
Oliver Fernando,
RaulfHeimsoth Monika,
Rihs HansPeter,
Barber Domingo,
Boquete Manuel,
Nieto Antonio,
Mazón Angel
Publication year - 2006
Publication title -
pediatric allergy and immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.269
H-Index - 89
eISSN - 1399-3038
pISSN - 0905-6157
DOI - 10.1111/j.1399-3038.2005.00341.x
Subject(s) - medicine , immunoglobulin e , group b , immunology , sensitization , allergen , latex allergy , group a , spina bifida , antibody , allergy , pediatrics
Single recombinant latex allergens permit the study of the pattern of sensitization to individual allergens. We aimed to quantify the IgE‐response to individual latex allergens in children sensitized to latex. The study group included 31 latex‐sensitized children: 26 operated at least twice, 20 of them with spina bifida; two children with one operation and three atopic non‐operated children. IgE antibodies to rHev b 1, rHev b 3, rHev b 5, rHev b 6.01, rHev b 7.02 and rHev b 8, coupled to ImmunoCAPs, were measured in each serum. IgE responses to rHev b 1, rHev b 5 and rHev b 6.01 were found in 17 children each, and their mean ± s.d. levels were 5 ± 7.4, 16.8 ± 14 and 10 ± 18 kU/l, respectively. IgE responses to rHev b 3 (4 ± 5.4 kU/l) were found in eight children. Two children had IgE to rHev b 7 (1.7 and 3.2 kU/l), and none to rHev b 8. Four sera were negative to all tested recombinant allergens. We divided the patients in three groups: sensitized only to rHev b 1, sensitized only to rHev b 5 and/or rHev b 6.01, and sensitized to both rHev b 1 and to rHev b 5 and/or rHev b 6.01. The three groups had the same profile of clinical features. Hev b 5 induces the quantitatively higher IgE responses in children with multiple surgeries sensitized to latex. Responses to Hev b 6.01 equal those of Hev b 1.